DOUBLE-HEADED MONSTROSITY.

A double-headed polyp

A 50-year-old man was seen as an outpatient for isolated, minimal and intermittent lower gastrointestinal bleeding. He had a history of well-controlled hypertension and diabetes. During his colonoscopy, a polyp with two heads that shared a common long and large stalk was encountered in the sigmoid colon (Fig. 1A). The heads were approximately 2 cm and 3 cm in size. Because of their overall size...

A Double-Headed Monster

A Double-Headed Monster

A double-headed monster was born in the Railway Hospital, Samastipur, on 5th July, 1948. It is an interesting case because of its rarity; the photograph (plate XXII) tells its own story. Dr. Mody, in his jurisprudence, gives a picture of such monster without any detail. The woman was a sweeper by caste, second para, and fairly well built. She came to hospital in a precarious condition, having b...

Exhibition of a Monstrosity

A double-headed cathepsin B inhibitor devoid of warhead.

Most synthetic inhibitors of peptidases have been targeted to the active site for inhibiting catalysis through reversible competition with the substrate or by covalent modification of catalytic groups. Cathepsin B is unique among the cysteine peptidase for the presence of a flexible segment, known as the occluding loop, which can block the primed subsites of the substrate binding cleft. With th...